Saint Joseph’s Translational Research Institute is pleased to announce the addition of the SJTRI Journal Club to the SJHA campus. Our move of the journal club seminar venue over to the hospital represents an important bridge we are building form SJTRI Preclinical to SJTRI Clinical, Saint Joseph’s Hospital of Atlanta, and the Saint Joseph's Heart and Vascular Institute.

We encourage anyone who is interested in attending the seminars at the hospital to join us and discover how the biomedical scientific backgrounds of our research endeavors translate from the bench to the patient bedside. Additionally, assisting in translating how your day-to-day activities can help move medical science forward; we encourage attendees to approach any of the scientific staff with questions for discussion.

If you are interested in attending, please contact one of our schedulers to reserve a time at (678) 843-6501

Bone marrow-derived progenitor cells have been used clinically to improve left ventricular function in patients after myocardial infarction however the mechanisms for this improvement have not been clearly defined.

Progenitor cell production of IL-10 may act to reduce T-cell infiltration in the infarcted myocardium and as a consequence, reducing inflammation while preserving contractile function in existing myocytes and maintaining blood flow in vessels.

Associated Documents

• Interleukin-10 From Transplanted Bone Marrow Mononuclear Cells Contributes to Cardiac Protection After Myocardial Infarction

Although the underlying mechanisms of LST are poorly understood, endothelial re-growth is an essential to provide critical structural and antithrombotic functions". Dr. Virmani’s team investigated stent coverage by endothelium post implanting either BMS, or DES eluting sirolimus, paclitaxel, zotarolimus, or everolimus in an endothelial denuded rabbits iliac.

At 14 days, the best result was seen only for everolimus-eluting stent and BMS. At 28 days, there was no difference between all stent types. "This finding may be of clinical importance because dysfunctional endothelium combined with a lack of endothelial coverage MAY play a role in late stent thrombosis

Associated Documents

• Endo Recovery among DESs JACC 2008